Neuronal activity increases translocator protein (TSPO) levels
نویسندگان
چکیده
منابع مشابه
An Updated View of Translocator Protein (TSPO)
Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys. This protein participates in a variety of cellular functions, including cholesterol transport, steroid hormone synthesis, mitochondrial respi...
متن کاملTranslocator Protein (TSPO) Role in Aging and Alzheimer’s Disease
Cellular damage and deregulated apoptotic cell death lead to functional impairment, and a main consequence of these events is aging. Cellular damage is initiated by different stress/risk factors such as oxidative stress, inflammation, and heavy metals. These stress/risk factors affect the cellular homeostasis by altering methylation status of several aging and Alzheimer's disease associated gen...
متن کاملBacterial Ortholog of Mammalian Translocator Protein (TSPO) with Virulence Regulating Activity
The translocator protein (TSPO), previously designated as peripheral-type benzodiazepine receptor, is a protein mainly located in the outer mitochondrial membrane of eukaryotic cells. TSPO is implicated in major physiological functions and functionally associated with other proteins such as the voltage-dependent anionic channel, also designated as mitochondrial porin. Surprisingly, a TSPO-relat...
متن کاملاثرات تزریق ارکسینA به درون بطن سوم مغزی بر بیان ژن Translocator protein (TSPO) در تخمدان موش های آندروژنه بالغ
هدف: اثرات تزریق ارکسینA به درون بطن سوم مغز بر بیان ژن TSPO در تخمدان موش‌های آندروژنه (AND) بالغ و تاثیر آن بر روی سنتز استرویید‌‌‌‌‌‌‌‌‌‌‌‌‌‍‌‍‌های ضروری در تولید مثل بررسی شد. مواد و روشها: بیست و چهار سر موش صحرایی ماده سه روزه در گروه‌های شش‌تایی با تزریق زیر پوستی تستوسترون پروپیونات آندروژنه شدند و شش سر موش ماده دیگر بهعنوان گروه کنترل انتخاب شدند. بعد از بلوغ حیوانات در 5 گروه شش‌ت...
متن کاملStress sensitivity in patients with atopic dermatitis in relation to the translocator protein 18 kDa (TSPO).
Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by pruritic and eczematous skin lesions and dermatitis that worsens under stressful conditions. However, the relation of these symptoms to an individual's stress sensitivity is not well understood. On the other hand, expression of the translocator protein (18 kDa) (TSPO), formerly known as the peripheral-type benzodiaz...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2020
ISSN: 1359-4184,1476-5578
DOI: 10.1038/s41380-020-0745-1